[Nemo]

Interesting thread. My list includes two already mentioned books and a couple more:

Jitterbug Perfume, Tom Robbins (novel)
Funny / philosophical / irreverent / makes me feel good to read it.

Surely You're Joking, Mr. Feynmann, Richard Feynmann
Cool autobiographical stories about Feynmann (Nobel winning physicist with a big sense of humor). I want to be like this guy.

The Demon Haunted World: Science as a Candle in the Dark, Carl Sagan
Sagan's best and last book. He was a true champion for science.

The Singularity is Near, Ray Kurzweil
Speculative book about our technological future that might blow your mind.

Cryptonomicon, Neil Stephenson (novel)
Amazing, amazing writing. His other stuff is great, too. The others inspire me, but this one is merely a masterpiece that should appeal to people who are into science and technology.