The Orlando regional is held at the UCF arena which can hold over 9,000 people. Inside the arena are several of the normal arena food places, along with a jimmy johns, but being in the heart of the campus within walking distance are a Papa Johns, Starbucks, Burger King, and more all on Campus. Though I am not entirely familiar with all of the restaurants in the area we have never had issues with finding a place to chow down for dinner (Bubbalou's is always popular after Saturday with between 3-8 teams showing up)
There are more than 10 hotels within two miles of the arena and all are used to us all showing up, and the Orlando International airport is a 20 min drive from the arena. My team has never had to utilize public transport but depending on the size of your team it might be more convenient to rent vehicles, which isn't very expensive for the convenience it gives.
It is Orlando do I really need to tell you what there is to do in the area? Though if you are worried about money :
http://myoldtownusa.com/
Is free to enter has a lot of shops to browse and has several rides that are pay per rides
Anymore questions? (Initial registration has only 11 slots of our 54 left so time is ticking)
Edit: I just now noticed your team location 125 and 348 are going from Massachusetts this year if you want someone to split costs with I am sure they would be more than willing