"ISS (Is Somebody Singing)"
Watch the video as astronaut Chris Hadfield, from aboard the International Space Station, performs "I.S.S. (Is Somebody Singing)" with Ed Robertson, the rest of the Barenaked Ladies and the Wexford Gleeks from Wexford Collegiate School for the Arts.
(And the geek in me kept wondering "How did they do that?" since there is a noticeable round trip delay from earth to the ISS and back. Keeping in time would be hard.)