[pfreivald]

In doing research for a novel, I searched for the worst possible place, crime-wise, in the whole country, and I found East St. Louis, Illinois... which is right across the Eads Bridge, a few blocks from the Edward Jones Dome.

My numbers are a few years out of date, but at the time East St. Louis had, compared to the national average:

Murder rate 20x.
Assault rate 17x.
Rape rate 8x.
Robbery rate 6.5x.

Fortunately the river helps; the City of St. Louis fares better than its eponymous neighbor, but not enough to make anyone comfortable. They're at 7.5x, 4.5x, 2x, 6x, respectively. For large cities, only Detroit and Flint fare worse.

That said, large groups are almost always insulated from all of the above; this means that being safe is a matter of awareness and common sense--stay in large groups, and don't wander off.