I found
Henry Thomas' videos on the Replicator 2 to be quite helpful. The videos at the end of the series are more informative.
We came right out of the gate printing a series of rather large parts, on the order of 11x6x4" and ran into some real headaches with parts being very difficult to remove from the build platform, as well as rafts/supports being nearly impossible to remove from the part, and areas of the build platform being prone to warped prints (when printing with stock firmware in makerware using "standard" setting with blue tape on the build platform).
For the past week we've been printing with no blue tape, right on the frosty side of the build platform.
No rafts. Parts are flat and can be removed from the platform easily by hand. There's also been no problems with adherence to the build platform (eg the first layer sticks). The key is to prep the build platform with olive oil prior to starting a print, as described in the videos linked above. A small dab spread across the build platform until it is translucent. Then wipe it off with a clean cloth. There seems to be enough residual olive oil on the platform to allow part removal, but not too much to prevent adherence.
We are still using makerware for the time being, tests with replicator G showed that the rafts were much easier to separate from the printed part(prior to us implementing the olive oil method).
We likely still have a problem with parts warping in areas of the build platform. It seems that the build platform may not be level across its length. The distance from the extruder nozzle at the far left and right of the build platform is invariable further away from the platform surface during calibration. I'm in the process of mounting a dial indicator to the extruder to take more accurate measurements and determine what the source of the problem is.
Those who are using rep. G, did you find slicing times to be significantly longer than makerware? I was printing a very large part at the time I used it, but it took over 5x longer to slice in rep. g than makerware. I've read that installing pypy can help. What's been your experience?