[PayneTrain]

I remember the Monday after the 2010 New Jersey Regional my sophomore year for being... difficult. You either take the day off on Thursday or your body wishes you take the Monday off.

That being said, regionals that attract a very local crowd (>85% of the teams within a 2.5 hour drive) might be better suited with a Friday-Sunday schedule (which I assume is the makeup of the Fri-Sun California regionals).