[GeeTwo]

A neat trick that works for some applications is to use perforated breadboard to line things up. The holes are already present at 0.1" apart, so if you can work out your spacings on that grid and fit pieces within a relatively small area, it's great. Just mark which holes to drill, and line up on these as pilots. If you're going to do multiple copies of a piece, use a 1/16" bit as a pilot for your stock, then follow up with the actual size hole. This trick is especially useful for making "control panels" and similar applications where you want everything to line up evenly, but exactly WHAT the spacing is isn't critical. OBTW, use the stuff WITHOUT solder pads for this!