The spike has been tested for the relay ports. I don't know if they have been tested for a DIO pin. The specs are different. The NI guys say the RoboRIO IO have been tested by teenagers & is nearly indestructible. But I am superstitious (or maybe I have more efficient teenagers.
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The input voltage for the spike's relay section is 12V nominal. I do not know if it will work at 5v.