Seems to be an older version of this:
http://www.super-tech.com/root/ITM-EMC-MightyBox.html
Need Mach3 or similar to control the mill with G-code.
Mach3 will use the DB25 parallel port interface on that PCB.
The PCB is a driver for the stepper motors.
That interface depends on accurate step timing from the parallel port - so it might not work right on some PC.
To configure Mach3 you will need to determine things like the turns per inch of the axis.
Also how many steps per stepper full revolution.
I would recommend the Gecko G540 to replace it.
http://www.geckodrive.com/geckodrive...ives/g540.html
However make sure to call Gecko with the stepper information before you consider that. I can not see the labels.