[Fusion_Clint]

Depends on your printer, some may even be able to print the threads for you.

If you plan on drilling and tapping, you have to make sure the hole placement will have enough "stuff" for you to tap the threads into. As most 3D printers, use some form of internal honeycombing technique on the parts to conserve filament.

If the part is designed right what you ask is possible, however you must consider if the materiel your 3D printer uses is strong enough for the task.