Although not strictly "senior pranks" some of the very best pranks are the "hacks" that periodically take place at MIT.
The "Great Dome" on top of Building 10 in the middle of campus is a favorite target. Some of the best hacks on the Dome include the
campus police car on the Dome and
turning the Dome into R2-D2.
But my very favorite was when Dr. Charles Vest arrived on his first day as the new president of MIT in 1990, they managed to
hide his whole office!
For a good archive of MIT "hacks"
check here.
-dave
(Adam and Carolyn - are you paying attention?

)
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I'm not impatient. The world is too slow.