Since we're in the business of over-analysis, I thought I'd share my immediate thoughts.
The clue kind of reminds me of a clue from a cryptic crossword, wherein oftentimes you have to find hidden meanings through anagrams. (Usually the anagrams are triggered by words such as 'crazy' or 'mixed', but there isn't anything of the sort in this particular clue, which leads me to believe that I'm barking up the wrong tree, but then again who isn't?)
So I've found a few anagrams for the phrase 'pi, you and me', and I've come up with some incredibly useless things, but mildly amusing nonetheless:
Yup, I'm anode
Yea, impound!
You'd pain me
Aim upon dye
Nude myopia
These were some that jumped out at me.
Like I said, in cryptic crosswords, there are usually triggering words, like 'between pi, you and me' could mean that there is a word in order within the letters of those words. (Like the country name 'hungary' in 'don't shun Gary, he just wants to play', which is from a book I had as a younger child).
It's a slightly different way of thinking, which is what first is all about, right?
Anyway, I hope kickoff weekend is great for everyone.