Personally I find the loading effects annoying - a lot of people say "I don't want to wait for it! Load it now!" Is the Javascript loading really necessary or can you just use a standard browsing? Especially the fade in is rather annoying. At school (which has bad computers) it actually takes a while to work. The scrolling pages looks nice, but again - it takes time.
Looks great, but I'm not sure its the most effective way.
