[Jeff Rodriguez]

I used Dvorak on my desktop for a few months now. I was good at it, until I got my laptop. I've thought about switching my laptop to dvorak.
Like Pat said, the biggest problem is that no one uses it. Every other computer you will come across has a Qwerty keyboard. It can also be a pain for shortcut keys (ctrl+c, ctrl+v). Many people are used to hitting shortcut keys very quickly, and moving them will mess you up.
One of the first things I noticed after using a dvorak keyboard is that you do much less reaching and stretching for keys. It's much easier on the hands. I highly recommend dvorak if you do a lot of typing, especially if you're at the computer all day.
Also, it does wonders for security. If someone gets physical access to your machine, chances are they don't know dvorak. They won't be able to do anything because it will take them half an hour to type something as long as thins post.