Yes you can modify them. Use them as is if you want, but I would recommend getting them with the precision bearings to match your axle diameter. The stamped bearings will fail. Prices are very reasonable. You will need to make adapters to drive them and space chain if you use chain. I believe Innovation First made hub adapters that still might be available that make it an easier mount if you use chain and sprockets. They were in the KOP when Skyway wheels were offerred.
PS -- AndyMark still has stock (last time I looked) of last year's wheels available, which ae softer. Hoevr some of them faled at he bearing and/or spoke areas, and were beefed up for this year's version. We modified them by filling in the hub space with epoxy/fiberglass to take the hard side hits that caused the bearing to break out of the hub rim.