I redid the portions of our site that used Lightbox to use
Shadowbox instead. It is by far the most flexible script like this, and allows for almost anything to be put in a lightbox.
In addition, it can resize images (in the browser) to fit any screen. I decided to redo our medium size images with 1024x768 images, which look great now.
I also redid the videos so that Shadowbox loads a 640x480 iframe with the video player inside. This is activated by clicking the Videos link in Site Links, and then pops up on any page.
http://www.dulaneyrobotics.com/index.php?pid=gall and check out the Videos link on the left