Team 612 has found the easiest drivetrain to build and use is the 6 wheel drive train (along with everyone else in the thread). I'll save time and not explain the benefits of this drivetrain as our fellow FIRSTer's have clearly explained this in previous posts.
One suggestion for building your 6 wheel drive train is the use of Belts and Pulleys rather than chains. They save lots of weight and are just as strong if not stronger than chains. Belt and pulley suppliers (ex. Gates) will provide you with the correct spacings for your belts and pulleys to ensure the perfect tensioning, this can help you if you CAD your robot. Along with that belts don't stretch (slightly if anything) but not as much as chains do. Before 2007 my team used chains and had numerous problems. Once we switched to belts in 2007 we have been hooked.
Here is a picture of our belt setup, if you have any other questions please feel free to PM me.
http://www.chantillyrobotics.com/photo_gallery/main.php?g2_view=core.DownloadItem&g2_itemId=6177& g2_serialNumber=2
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2008 NASA/VCU Chrysler Team Spirit Award
2008 Buckeye KPC&B Entrepreunership
2008 Buckeye Regional Chairman's Award