Expected loads
Fudge room for impacts and competition
Packaging space
What you used the last time that worked
Overlap length in the sections
If you don’t know about the effects of L/D ratio on sliders, you -really- want to look it up.
Radial load rating for the bearings
Number of bearings used
Load sharing between multiple bearings
Acceptable friction (in case you use sliders rather than bearings).
The contact stresses between the bearings and the rails they run on are probably not a major factor in FRC; Aluminum vs steel spreads the load a LOT more than hard steel on hard steel. Nylon tires on Aluminum spreads it even better!
Keep in mind that your factor of safety needs to be related to how much you know about the system and how its used. In the case of FRC, our knowledge of what’s going to happen in competition is poor. We can design around the known loads, but we need a lot of room for “oops I just ran into the scale at top speed” or “I ran the elevator up into the bottom of something”.

See my almost-exactly constrained 3D printer design: 

